1、意思上的区别：

make jokes about：讲笑话，开玩笑。

make jokes on：拿…开玩笑。

2、用法区别

make jokes about 后面一般接something（某件事）。

make jokes on 后面一般接somebody（某人）。

3、例句：

①、make jokes about

They often make jokes about my bald head.
他们常拿我的秃顶开玩笑。

Don’t laugh at, stare at or make jokes about disabled people.
不要嘲笑，盯着或是拿残疾人开玩笑。

They make jokes about the way I wear glasses.
他们取笑我戴眼镜的样子。

②、make jokes on

I could just laugh loudly and make jokes on someone who can accept certain degree of humor.
我可以尽情地大笑，尽情地开玩笑，因为那些人不会因为一些小事就和我绝交。